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Desk one summarizes the observed DLTs by cohort. Somnolence, which solved in all but one individual, was the only DLT for MLN8054 supplied without methylphenidate or modafinil. The onset of somnolence and its severity frequently have been correlated with dose and Cmax. Simply because somnolence was regarded as connected to Cmax, the dosing timetabl
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